Giorgia Tosoni

Curious mind striving to decipher the link between adult neurogenesis and Alzheimer’s disease, at single-cell level. Boosting my own neurogenesis climbing, running, cycling, and reading books. Molecular biologist by training, with my PhD project I am embarking into the bioinformatics world. My interest is to map the cellular and molecular complexity of the human adult hippocampal neurogenic niche and investigate which are the cell-types and the pathways that may be deregulated in Alzheimer’s disease (AD). To achieve this goal, I profit from the presence of the Netherlands Brain Bank (NBB) in our institute to obtain a carefully selected and stratified collection of post-mortem fresh-frozen human hippocampi, from healthy, AD, and ‘dementia-resilient’ individuals. By using single-cell technologies I hope to characterize hub regulators of adult hippocampal neurogenesis and their potential role(s) in the development of AD.