Key publications

van Elzelingen, W., Goedhoop, J., Warnaar, P., Denys, D., Arbab, T., & Willuhn, I. A unidirectional but not uniform striatal landscape of dopamine signaling for motivational stimuli. Proceedings of the National Academy of Sciences (2022)

van Elzelingen, W., Warnaar, P., Matos, J., Bastet, W., Jonkman, R., Smulders, D., … & Willuhn, I. Striatal dopamine signals are region specific and temporally stable across action-sequence habit formation. Current Biology (2022)

I Ehmer, Crown L, van Leeuwen W, Feenstra M, Willuhn I, Denys D. Evidence for distinct forms of compulsivity in the SAPAP3 mutant-mouse model for obsessive-compulsive disorder eNeuro (2020) 

Ehmer I, Feenstra M, Willuhn I, Denys D. Instrumental learning in a mouse model for obsessive-compulsive disorder Neurobiology of Learning and Memory (2020) 

de Groot A, van den Boom B, van Genderen RM, Coppens J, van Veldhuijzen J, Bos J, Hoedemaker H, Negrello M, Willuhn I, De Zeeuw CI, Hoogland TM. NINscope, a versatile miniscope for multi-region circuit investigations eLife (2020)

van den Boom BJG, Mooij AH, Misevičiūtėa I, Denys D, Willuhn. Behavioral flexibility in a mouse model for OCD: impaired Pavlovian reversal learning in SAPAP3 mutants Genes, Brain and Behavior (2019)

Pinhal C, van den Boom BJG, Santana-Kragelund F, Fellinger L, Bech P, Hamelink R, Feng G, Willuhn I, Feenstra MGP, Denys D. Differential effects of deep brain stimulation of the internal capsule and the striatum on excessive grooming in Sapap3 mutant mice Biol Psychiatry (2018)

Figee M, Pattij T, Willuhn I, Luigjes J, van den Brink W, Goudriaan A, Potenza MN, Robbins TW, Denys D. Compulsivity in obsessive-compulsive disorder and addictions European Neuropsychopharmacology (2016)

Klanker M, Sandberg T, Joosten R, Willuhn I, Feenstra MGP, Denys D. Phasic dopamine release induced by positive feedback predicts individual differences in reversal learning Neurobiology of Learning and Memory (2015)

Willuhn I, Burgeno LM, Groblewski PA, Phillips PEM. Excessive cocaine use results from decreased phasic dopamine signaling in the striatum Nature Neuroscience (2014)

Figee M, Luigjes J, Smolders R, Valencia-Alfonso CE, van Wingen G, De Kwaadsteniet B, Mantione M, Ooms P, De Koning P, Vulink N, Levar N, Droge L, van den Munckhof P,  Schuurman PR, Nederveen A, van den Brink W, Mazaheri A, Vink M, Denys D. Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. Nature Neuroscience (2013)

Willuhn I, Burgeno LM, Everitt BJ, Phillips PE. Hierarchical recruitment of phasic dopamine signaling in the striatum during the progression of cocaine use. Proc Natl Acad Sci U S A (2012)